Tolerance can vary
People may experience discomfort during an infusion. Symptoms must be assessed in context rather than dismissed as proof that the treatment is working.
Patient guide · NAD+ IV
A practical guide to tolerance, monitoring, escalation and why infusion speed and clinical context matter.
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People may experience discomfort during an infusion. Symptoms must be assessed in context rather than dismissed as proof that the treatment is working.
A supervised service must be able to slow or stop administration, reassess the patient, document the event and escalate when clinically necessary.
Dose, duration, tolerance and symptoms belong in the clinical record. A repeat session should not ignore what happened previously.
Connected clinical library
Dose, duration, cost, evidence, tolerance and the clinical checks that connect them.
Direct answers
Tell the attending clinician immediately. The clinical team decides whether to slow, stop, assess or escalate; do not self-manage an active IV reaction.
No. Symptoms during treatment require clinical assessment and should not be reframed automatically as efficacy.
Evidence position
Sources used for this page
Human studyGrant et al.: intravenous NAD+ metabolome pilot (2019) ↗Direct six-hour IV NAD+ administration and measured metabolic changes; a small pilot, not proof of broad clinical benefit.Human studyReal-world IV NAD+ and IV NR tolerability pilot (2026) ↗Exploratory infusion duration, symptoms and short-term biomarkers; retrospective data, not an efficacy trial.Scientific reviewVerdin: NAD+ in ageing, metabolism and neurodegeneration (2015) ↗Established NAD+ biology and mechanistic context; it does not establish outcomes from IV therapy.Your first message · Where you are + what you need help with